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Try powering off the phone for a few minutes, then power back on and try syncing again. I've had the problem this past weekend and that worked for me. YMMV though.
White MacBook 2GHz CD/2GB RAM/320GB Hard Drive - Mac OS X 10.6.7
iMac Core i3 3.06GHz/8GB RAM/500GB Hard Drive - Mac OS X 10.6.7
Mac mini 1.83GHz C2D/2GB RAM/80GB Hard Drive - Mac OS X 10.6.7
I connected my iPhone to my computer, let it do a full backup and then restored it. Amazingly, when I used the backup to recover the data, it even kept all of my app preferences (saved games, stats, etc.).