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Try powering off the phone for a few minutes, then power back on and try syncing again. I've had the problem this past weekend and that worked for me. YMMV though.
MacBook Pro 13" 2.8GHz Core i7/8GB RAM/750GB Hard Drive - Mac OS X 10.7.3
I connected my iPhone to my computer, let it do a full backup and then restored it. Amazingly, when I used the backup to recover the data, it even kept all of my app preferences (saved games, stats, etc.).