The MuVo will work with OS X without issue--that is--until it stops working. Sometimes, the flash drive becomes corrupt, and then you have to reformat it with a special app on the PC. There is no equivalent app for the Mac. I guess creative never heard of the Java programming language, and its ability to work on a variety of platforms. Anyway, once the MuVo becomes corrupt (and it will happen), it's a very light paperweight. If you have VPC then you can resurrect it.