I have the Epson 1660. There are drivers for OS X and it works great. There is only one problem, you'll need a 3rd party program, as the image capture built into os x will not scan negatives for some reason. I have photoshop 7, and as soon as I remove the reflective lid the negative scanner turns right on, and photoshop knows exactly what to do. You can't go wrong with this scanner in my opinion.
Anim8r