You sure can. The only thing to keep in mind is that in order to program the ExposeL hotkey into the Powermate software, you have to disable it first. By that I mean that if you have F9 be one of your hotkeys, in order to set that to the powermate, you have to temporarily set it to F1 or something, or else it won't take (it'll just activate ExposeL instead). It's pretty cool with a powermate.