I have problem too, with a new macmini and Tiger. It works only with the predefiend buttons (such as play, stop, forward and so on). But if I want to get to the advanced feautures, and program for example that 1 on remote should be Command+F, thats not possible anymore.
Ive been in touch with callsupport, and the told me they should chack it out, but hounestly... Seems like they eigther had to few error reports, or that the product is to cheap. I think they give it up.
Grrr - i really used their advanced features. Please, mail them your problems so they at least consider making a new driver.