It depends on a lot of things. Are 750GB drives taller than a standard half-height internal drive? Does the support chipset in the enclosure have the ability to address that large a drive? (Yes, the controller does have to be compatible with the drive, and frankly, 750GB drives are not exactly common, so it's quite possible that inexpensive, or even really expensive enclosures don't yet support that size drive because they can't.)