eSATA with port multiplication uses a single SATA connection (either 1.5 or 3.0Gbps) as the interconnect, so you get 150MBps or 300MBps, not five times that. 52X CD is about what, 6 or 7 MBps, so you're not going to face any crunch there.
Port multiplication is standardized (so different companies products will work together), but not standard in the sense that all eSATA devices support it (most don't). If a device has it, they will mention it.
If a card doesn't advertise Mac compatibility, it probably won't work under OS X; should still work under Windows, though. You may find a card that doesn't advertise Mac compatibility that works with drivers from another card that does, but there's no guarantee there.
* There are some SATA port multiplier products that use Infiniband for the interconnect for better performance/distance, but they're ungodly expensive.