The difference (if any) would be infinitesimal. Somehow, people have perpetuated the idea that modern hardware has all the same problems and failings of stuff from 20 years ago. Hard drives are sometimes rated in hundreds of thousands of hours MTBF. Spin it all the time, spin it just a few seconds at a time, no problems. You might want to adjust the time delay for spin down to a slightly longer time-say 20-30 minutes-which would possibly reduce the wait time for some of your accesses. But I wouldn't worry about it.