I'm sorry, but at this present time it is not Mac OS X compatible.
Mac OS X 10.1.4 & Palm Desktop 4.0:
Doesn't work
Mac OS X 10.1.4 & Classic & Palm Desktop 2.6.3 & Missing Sync 2.2.1:
Works
Mac OS 9 & Palm Desktop 2.6.3 & Missing Sync 2.2.1:
Works
Mac OS X 10.1.4 & Virtual PC 5.02 & Windows 2000 & Sony Software:
Works (but slow)
You'll just have to do that or wait for Missing Sync 3