I routinely sync with my iMac at home and my PC at work. The only time I have had difficulties is in using the original conduits supplied with MS Entourage. Using the Palm Desktop at home and PocketMirror/Outlook 2000 at work has been flawless.
Can use AvantGo and Vindigo on both platforms as well.
The data on the Palm is platform-independant. It works well.