Working with itunes and toast are two different things. Almost any USB/IDE/FW cdrw should work with toast. I just searched around and it seems the older 12x drive was supported by itunes, but the only thing I could find about the 40x was some online store that said it worked with itunes. xlr8yourmac seems to be down right now, they might have a patch to make the 40x work, maybe. Did the drive could with a install CD? There might be a file to install that makes it work with itunes and disc buner, until xlr8yourmac is back up, I'd try that.