I've been using the delta 66 for about three years. Love the low latency, about 8ms in reason with asio drivers, also the virtual mixer makes a lot of sense, the breakout box, need I go on?
Also, I own a midisport 4x4 by midiman (M-audio)....depends how seriosu u are about the midi stuff, 4x4 gives ne plenty of options to route a growing studio. Hope this helps.