Sounds like you have the same problem I do. I've asked Apple about it, but no response...
Seems many people are having trouble like this, but here goes:
When opening an MPEG movie in IE, (I have QT 4 pro), I get the "The attempt to load <URL of movie> failed" error.
If I drag the link to the desktop, it saves the file as a quicktime creator, but as a wav file type (wav appears in the icon).
I can use FileTyper to change the file to MPEG type and creator TVOD so MoviePlayer will handle it just fine, but that is a pain. I've checked my file helpers and all looks fine - .mpg is type MPEG and creator is TVOD, binary data and handled with plugin...
I can't be sure, but all of this may have happened after I installed RealPlayer then realized how much it bites and removed it...
- A.