Not necessarily true:
I have a Rio 600, iTunes, and a Kensington Optical Pro mouse--with the latest Mouseworks software--and 9.1, and I have no problems.
I can only recommend that you make sure that you have two plugins, first, the USB plugin titled "USBRioDriver" in your Extensions Folder, and "Rio600 Plugin" in the Plug-ins

evice Plug-ins Folder of iTunes.
Good luck.