a)If you want smooth playback, keep the bitrate below about 3.5M/sec (that's megabytes) so it's 28Mbits/sec.
b)If you're not actually making VCD's you could drop the framerate from 25/30fps down to about 20/24, anything below that starts getting jerky.
c) Get Quicktime 4.1Pro (If you haven't already) gives you more control over compressions settings etc.
d) Again, if it's CD-ROM for your own use, try the frame size 384x288 (VCD/MPEG1 size, approx), it's a reasonable size for full speed playback, unless you really want 640x480/768x576 blown up to full-screen! Remember you're also dealing with IDE/ATA max data rates from your CD-ROM not just the capabilities of the CPU/Graphics Card.
e) Use Sorensen Compression (If you're not already) definitely the best quality vs bitrate compressor. (I'm sure 3,500,000 will now disagree with me!!!)
f) Sound, for quality try to leave sound alone (ie: uncompressed) it's already been sampled once, you could go from stereo to mono, or integer halve the sampling rate, or go from 16bit to 8bit. Compressors can give the sound a strange hollow phased effect. Compared to the video bit-rate, the sound is almost insignificant. I'd sacrifice a few K of video to keep reasonably listenable sound!
N.B. These are statements of personal opinion, I'm not trying to pass them off as fact, Gospel, a quotation from the Torah or even an extract from the Dead Sea Scrolls (2nd edition, addendum to Section 2, St.Paul's Letter to Sorensen)
[This message has been edited by Feathers (edited 03-24-2000).]