I was thinking about this as well the other day.
I've been messing around with *BSD and read that you can do headless installs by piping the output through the serial port instead of using a monitor. It's not a big deal for a PC where monitors are a dime a dozen, but for an old Sparc box that use funky monitors, it would be really handy to have a serial port.
Also, I was thinking of getting one of those Garmin Frontrunners for training, and it uses a serial port for sync'ing. If I had a serial port, I might be able to figure out the protocol and write some Cocoa software for it.
I see that Keyspan makes a PCI card with 4 Mac-type serial ports on it, so I wonder if a generic PC-type PCI card would work. You know it has to be like 10x cheaper than the Mac version.