This is one of the weirdest bugs I've encountered: I was noticing what seemed to be disk read errors on my new (less than a week old) rev A Dual 2.0. Specifically, iTunes playback would stutter any time either my primary 160Gb drive or secondary 200Gb drive would get accessed. This also led to some nasty crashes on saving out various files.
Apple Hardware Test, Disk First Aid, TechTool Deluxe didn't show anything wrong. DiskWarrior showed TONS of directory fragmentation. But fixing that didn't solve it.
After stripping everything out, it turns out, the PCI Radeon 7000 I had in there powering my second monitor was to blame. Pulling that fixed all the drive read issues and also sped up Expose like crazy. I've got an ADC->VGA adapter on order now to power the 2nd monitor.
Why a graphics card would do this, I have no idea. Weird, but true.
-n