I play it full screen on my 20" iMac. You do have to turn most of the settings down pretty far, but it still looks pretty good (the art direction is what's really great about the look of that game, so even if you lose some polygons and fancy 3D effects, it still looks great) and it runs fine. not super-smooth, but perfectly playable. You could run it at a lower widescreen resolution and it'll stretch it to full screen, which may give you slightly better performance, but it also makes the image slightly blurry, so i found that that wasn't worth it.