iMac 2007, Intel Core 2 Duo 2.33 Ghz, GeForce 7600 GT 256MB, 2 Gb RAM, 500 gb, etc.
OSX Tiger, the most recent update.
Anyway, I think the solution maybe power surges. I was playing WoW and I had it flicker on me again but it was constant for about 10-15 seconds, then it just stopped.
I went ahead and put "Sleep" to never activate. But I did leave display on to 10 minutes.
I resetted the PRAM, and everything seems to be fine now...