I've had a handful of really top-notch monitors over the years, and, at the time, they were beautiful to work with. One aspect of CRTs I don't miss, though, is how tired my eyes were after a day of staring at a 21" tube. It wasn't the brightness, though. The way my doctor explained it to me was, because of the way any screen (crt or lcd) is made, there are essentially two surfaces your eyes try to focus on. The outer top layer, and the lower layer that the image is actually displayed on. Your eyes are constantly bouncing their focus between those two surfaces.
With LCDs, the distance between those layers is pretty small, so the work your eyes do is pretty negligible. Add a non-glare screen (like on my beloved 23" Cinema HD display) and the effective work drops to nil. On a tube, though, the distance between the outer surface of the glass and the actual image plane is relatively huge, and your eyes work themselves to death, constantly searching for the focal surface. Also, you have to add-in the flicker a tube produces even at the highest refresh rates. At the end of a long day doing graphics on a big tube, your eyes are fried.
I also don't miss how much space a big tube took up on my desktop.