Um.
Don't just unplug the iPod.
you need to unmount (eject) it, either from iTunes, or, if it's mounted as a removable hard disk, from the Finder.
Neither that nor the mouse should crash your Mac, though. Just unplugging the iPod should throw up a dialog box saying something like "The volume you have removed has not been properly put away. If you do it this way, you may damage the filesystem, resulting in data loss or corruption."
Does the 'book's hard drive come on (the faint whirring sound) and the monitor just stay dark, or is the machine off entirely?
what kind of mouse? did you install specific drivers for it?
unplugging my USB audio interface while the 'book is sleeping will kill it occasionally, as well. This is due to a faulty driver (**** tascam).
-s*