2 GB SO-DIMMs have been out for a while now. The ones the MB uses are exactly the same type you find in the MBP: PC-5300.
The Napa chipset supports 4 GB, but software can't address ~800 MB of the last GB. Therefore people usually update to 3 GB rather than to 4 GB. You would be paying a whole lot of money for those 200 MB.
Dual-channel memory access shows benefits on Macs with shared VRAM. So on a MB you will probably measure a difference if you look at 3D games or apps that rely on GPU performance. If you benchmark CPU-limited tasks the gains form dual-channel memory access are basically zero. However, if you are suffering from a performance decrease due to a lack of RAM (lots of page-outs), adding RAM is going to help a lot regardless of dual-channel memory access. BareFeats has looked at this in the past.
Much of this stuff has been discussed already on this board. Try a forum search for more information.