Intel Macs can boot from USB, PPC Macs can only boot from FireWire. As long as you've got an Intel Mac and the drive partition scheme is right (GUID) you can boot from it. Now, keep in mind, transfers (such as cloning via SuperDuper!) is much slower over USB than FireWire, as with actual system performance once you do boot from it. If you're -just- using it for backups, though, and you'd only boot from it if absolutely necessary, you'll be fine.