With RC-5, tweaking is not really an issue for the Mac, once the cores are optimized and the latest version is.
The big difference is the CPU. A G3 CPU will hold its own on an equal megahertz basis and then some, but it is the Altivec (SIMD) enabled G4's that really shine at RC-5.
OS wise, RC5-72 requires the OS-X/darwin client. It will not run on the much older OS-9 clients (though OGR will).
You want client version v2.9003.481 for the best optimized cores but might have to download it from the pre-release/beta page at
http://www.distributed.net/download/prerelease.html However, it is actually a final release now.
Oh, to check the OS version, while in the finder go to the "Apple menu" (apple icon) at the top left corner and select "About this Mac". That will give you the System version.
How fast is it?? My 800mhz PowerMac G4 will outcrunch my Athlon 2400 running Win XP by a little. Even the fastest P4's can't come near it on RC-5.