It's due to the way that many games change their resolution during start up and close of the game, I'm not sure on the exact details, but I know that a lot of games change change the resolution and my popup folders don't fit anymore, and if a game doesn't blank out my second monitor it's funny to see the icons jumping arround on that monitor when the game changes res
diablo changes res between 800 x 600 and 640 x 480 for ingame and trailersm and I had the same thing with 4 x 4.