I say try it. I'm running MOSX from a partition on my main drive on an "unsupported" 7300/180 with an ATI Xclaim 3D card and while there was a glitch for me right at the end of the installation sequence (hung doing config at end of setup mgr), it has worked fine since. Onm a supported configuration like this, there shouldn't be any problem so long as you partition your disk carefully. Do a backup.
I am finding that I'm using a fair bit of my unix knowledge but that might just be with my unfamiliarity with the Window Manager, it's very OpenStep.
Ben.