I have this problem in Safari where opening the font panel from the "Appearance" pane in the preferences won't let me select any typefaces. It will show the "Collections" and "Family" columns, but the "Typeface" column refuses to show, unless I choose "Edit Sizes" from the actions menu at the bottom of the panel. However, I can't select any of the faces because the "Edit Sizes" sheet has the focus.
Is anyone else experiencing this problem, or does anyone know of any fixes? I've tried everything short of a fresh install (including permissions, caches, re-installing Safari and the combo updater for 10.3.8, and digging through various .plist files), and that will be my last resort. No haxies or other system modifications are running on my machine.