I recommend the better (and more modestly priced) Keyboard Maestro or iKey instead of the overpriced QuicKeys for full GUI scripting -- or even just the much-recommended, lovely, and free Quicksilver for hot key triggers.
I don't think Automator will kill any of these macro applications, FWIW; it's a slightly different beast, isn't it? But I should really wait until I get a chance to use it before making any grand pronouncements.
