I generally leave about 1.5 gb free on my main partition... I know that's "cutting it close" but the rest of my partitions are full, too, so until I get a new HD, that's the way things are going to be.
I'll watch as after only 2h of running, swap space encroaches upon the disk until there's 94 mb (!!!) remaining, at which point ALL OF MY PREFERENCES GET TRASHED.
Now the memory leak is one issue.
But why does OS X trash all of your preferences when disk space gets low? Is there any logical explanation for this before? It's happened to me three times now and it's just not cool.