Originally posted by chris v:
Just download Carbon Copy Cloner and set it to clone your boot drive to your firewire drive every few days in the middle of the night. It's amazingly simple.
CV
I second that. I've probably done 100 "oops, I didn't mean to delete that/save over that" restores for every harddrive failure restore. A weekly backup will have the potential to save you from that, while a RAID 1 allows you to have the same undesired file twice.
I use DejaVu to backup to my external firewire weekly, and Backup.app to store my most important data offsite.