This is a security warning to prevent e.g. trojans from launching a malware application without your knowledge. You don't want to disable it. If you are getting this warning every single time you launch an application, then there is something wrong with your install. However, be aware that if you update an application, the next time you double click a file to open it, you will receive the warning again. Does that sound like anything that has happened (e.g. an updater for Office was released this week, so did you apply it?).