Maybe it's just me, but I find OS X a little shotty with it's mice. I had a PPC Mac mini a while back, using a mighty mouse, and it would randomly jump across the screen from time to time. I'm using my iMac now and it does the same thing, using my mighty mouse and a logitech mx600.
I'm assuming this is merely a software related issue, seeing as how my mice are fine under windows on my iMac. But does anybody have a fix?
I don't use a mousepad, but the desk i'm using is, i think, oak, with a non-reflective finish so i can't see that being the issue.