I have 4 different machines all running OS 10.5.8 and have the Adobe CS2 suite (Illustrator, Photoshop, InDesign & GoLive) on them, and they all function fine.
(Same with Quark 6.5, but we could argue about how Quark functions, independent of the OS :-) )
Once in a while, Illustrator sends a file to a different printer than the one chosen in the print dialog, but it's random & very occasional. Not a huge deal.