Originally Posted by Walker
Sounds good. I'm guessing I'll be able to direct the path to iTunes and iPhoto libraries? How about the preferences for 3rd party apps?
All that stuff is stored in your home folder, not with the application. The physical location of the application is unimportant.
Will it just work because it's a Mac or will I have move them over to the startup disk?
It'll just work, because it's a Mac. The one thing is that with the default apps that come with OS X, you probably want to leave them in their default locations, because Software Update has a somewhat flimsy track record of updating apps that have moved. Third-party apps, though, can go anywhere.