Heya,
Personally, I use SimpleBackup and though you have to fire it up, it works fast and is easy to use; Versiontracker should have a copy somewhere. And if you've good with AppleScript, you can have it work automatically; add to this the fact that it works by you placing aliases of folders, drives or files inside the SimpleBackup folder and it's easy to change what you want backed up.
I've used it for years (the better part to 5 years) and find it to work seamlessly, fast and without some of the problems associated with other backup programmes that compress or segment your backup in ways you might not be able to use if things go wrong.