Personally, I would not work on the clone itself. I'd consider it safer to work on a clone of the clone so that you always have one backup clone that's left untouched. Of course if aside from that clone you have a TM backup too you already have enough redundancy.
The rules are quite simple: If the OS X version is newer than the Mac it's running on it will work.
Also, next time you do a clone use the built-in tools. Their free, fast, and more stable any of these commercial solutions. Cloning is built right into OS X. /Applications/Utilities/Disk Utility > Restore. Select erase destination to get a bootable clone in block copy mode (fast!).