I have a few things I'd like to scan, and a roommate with the D1250U2F scanner. This is a pretty good scanner, but unfortunately it's just about the only model that Canon doesn't seem to provide OS X support for. Why don't I just use my roommate's PC, you ask? Windows is so horrible with USB devices that it just doesn't work with it. Of course I looked up VueScan but it's not on their list of supported devices. I don't know if Canon's Toolbox software would work with this scanner at all.
Edit: I got it to work on the PC so it's OK.