I just picked this up yesterday. So far the gameplay doesn't seem nearly as crisp as in 09, but I've only played a couple of quick games so maybe I'll get used to it. The colour commentary doesn't seem to have as much colour as last year, either. Overall, Madden 09 was my favourite Madden ever and I was hoping that 10 would be even better, but it looks like it may have taken a step backwards again (no big surprise).
Who knows, though; one I get used to the new gameplay mechanics maybe the game will grow on me.