Maybe this is over simplified, but if you sign up and select all the applications on your prefs page, it will only send you work that is appropriate for your system. For instance Primegrid currently has a challenge in progress, but it's Windoze or Linux only so it won't let you select that app if you're running OS X.
Speaking of Primegrid, they say that having a 64 bit CPU is useful for the project. All Apple CPUs from the G5 forward are 64 bit, but 64 bit support varies between Tiger, Leopard, and Snow Leopard. Does the Primegrid app run in 64 bit mode in either Tiger or Leopard?
I wish OS X were fully supportive of 64 bit operation so that issues such as this wouldn't exist.