You're seeing a problem with the hard drive. Do you have a backup, in case you've lost it?
Boot from an OS CD and use Disk Utility. Select the internal drive icon, see what the SMART status is at the bottom of the window. Anything other than 'Verified' means you need a new hard drive.
If it shows as Verified, you may be able to repair it. You could let Disk Utility try if you're backed up, but Disk Utility doesn't do data recovery. If you aren't backed up, you might wish to use Disk Warrior, which will try hard to preserve your data.
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