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I am using 10.1.5 on a brand new iMac. After the unit goes to sleep (or screensaver mode) my printer, imation superdrive disk, and other usb peripherals will not work.
If I restart, everything again works perfectly.
Yes, this has happened to me a few times with my iSub. It seems to have forgotten that it was there. I didn't have to restart, only unplug/replug the USB connection.