I found at the problems with my serial ports are related to my keyspan USB card (many problems have been reported with this card and system 8.6). When I simply disconnected my USB connected Epson EX Photo printer from my keyspan USB card my serial port problems disappeared. I also have a Keyspan serial adapter hooked up to the second port of this USB card and my serial Wacom tablet connected to this USB port via the serial adapter works perfectly...what a mess huh? Anyway, I'm waiting for Keyspan to update their USB drivers. I can still use my Espson printer with my serial printer port