I just got a Logitech Wireless Access Combo (i'm only using the keyboard though) for my Cube and all the keys are fully programmable through the software they provide. I did DL the newest version of it form the Logitech website. I have the email key set to open Entourage, the messenger/sms key set to open iChat, the mute key does in fact mute my iSticks and the volume controls work. Also, I have the media key set to eject cd's, and the my home key opens my user directory. So in short, the keys are programmable. Also, the model that i got already had an apple (command) key setup and labeled.
dooger