RAID requires like-size drives. There is another system called "JBOD" (Just a Bunch Of Disks) that does what you are thinking.
But any time that you combine drives without adding redundancy data (as most RAID does), you are decreasing your data security.
Just keep them as separate disks and use them like that. (In fact, I'm not even sure of any way to do JBOD on a Mac, anyway.)
tooki